“Actually, Oregon grape has very interesting health properties. For one thing it contains berberine which inhibits PAK1. Its sort of…. berberine is to Oregon grape what CAPE is to propolis. You’ll see Oregon Grape or Oregon Grape root in a number of supplements for inflammation as it is also a cox2 inhibitor. Berberine normalizes skin cells too and so Oregon Grape is sometimes used for skin problems like eczema or psoriasis. Its one of those wide spectrum plants.
Maqui like many highly pigmented fruits (pomegranate, concord grape etc) contains the antioxidant delphinidin. Delphinidin appears to target a few pathways and growth factors as it effects blood vessels (via VEGF, ERK, PDGF etc). Its been looked it in a number of tumor lines including Gliobastoma and fibrosarcoma. As usual, no studies specific to NF related complications but you’ll find it interesting I think that anthocyanidins like delphinidin appear to have the ability to cross the blood brain barrier.
Dr. Beliveau, who you’ve heard me mention because he wrote two of my favorite books “Foods that Fight Cancer, Prevention of Cancer through Diet” and “Cooking with Foods that Fight Cancer” was involved with his co-author on an interesting paper that talks about how Delphinidin actually approaches Gleevec in some measurements.